(Depression with Atypical Features)
by Amy Scholten, MPH
Depression is a lasting low mood and lack of interest in doing things. In atypical depression, mood may improve for a short time. There are other symptoms that often do not occur with depression.
The exact cause of atypical depression is not known. It is probably due to changes in brain chemistry. Genes and environment likely play a role.
Things that may raise the risk of this condition are:
People with atypical depression have depression with short periods of improved mood. Mood gets better when something positive happens. It then goes back to being low. Other symptoms may be:
There are no tests to diagnose this condition. The doctor will ask about your symptoms and health history.
The doctor may give questionnaires. A physical exam and other tests may be done. They can help rule out other causes.
The goal is to improve mood and ease other symptoms. Options are:
Depression cannot always be prevented. However, the risk of symptoms may be lowered by:
Depression and Bipolar Support Alliance
Mental Health America
Canadian Mental Health Association
Canadian Psychiatric Association
Atypical depression. Mayo Clinic website. Available at:
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Accessed March 9, 2021.
Depression in older adults. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/depression-in-older-adults. Accessed March 9, 2021.
Juruena MF, Bocharova M, et al. Atypical depression and non-atypical depression: Is HPA axis function a biomarker? A systematic review. J Affect Disord. 2018;233:45-67.
Major depressive disorder. EBSCO DynaMed website. Available at: https://www.dynamed.com/condition/major-depressive-disorder-mdd. Accessed March 9, 2021.
Last reviewed January 2021 by EBSCO Medical Review Board Adrian Preda, MD
Last Updated: 3/9/2021
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