Risk Factors for Cold Sores (Herpes Simplex Type 1)

Risk Factors for Cold Sores (Herpes Simplex Type 1)

A risk factor is something that increases your likelihood of getting a disease or condition.

It is possible to develop cold sores with or without the risk factors listed below. However, the more risk factors you have, the greater your likelihood of developing cold sores.

The viruses that cause cold sores are easily spread. They come out of the skin and are “shed” from the site of the cold sore for 1-2 days before the sore appears. Then the virus is in the fluid of the cold sore blisters.

Once you have a herpes simplex infection, cold sores often form because of stress or illness. Some may form without an identifiable trigger.

Risk Factors for Becoming Infected With Herpes Simplex 1 Virus

Exposure to Someone With Cold Sores

Herpes simplex virus type 1 (HSV-1) can be spread by close contact with someone who has a cold sore. It can also be spread through personal items that are contaminated with the virus such as razors, towels, or eating utensils. Kissing or sharing personal items with a person who has a cold sore will increase your risk of getting HSV-1. The virus can also be spread to the genital area during oral sex. People with cold sores should not perform oral sex on their partners. The virus can be spread even when no cold sores are present.


Infants and young children up to 3 years old have an increased risk of being exposed to HSV-1.

Risk Factors for Developing Cold Sores Once You Have a Herpes Simplex Infection

Exposure to Sunlight

Exposure to sunlight or other ultraviolet light is a common trigger for cold sores.

Physical Stress and Illness

Stress on the body due to illness or excessive exercise can weaken the body’s immune system. This can lead to an outbreak of cold sores. Common examples of stress or illness include:

  • Infection, fever, or cold
  • Physical injury
  • Dental surgery
  • Menstruation
  • Medications and/or health conditions that suppress the immune system
  • Excessive exercise

Emotional Stress

Cold sore outbreaks commonly occur during times of emotional stress. The type of stress that activates cold sores is typically negative stress, instead of stress due to positive or normal life-changing events.



Herpes causes & risk factors. American Academy of Family Physicians Family Doctor website. Available at:
...(Click grey area to select URL)
Accessed January 29, 2021.
Herpes simplex. DermNet NZ website. Available at:
...(Click grey area to select URL)
Accessed January 29, 2021.
Kuehl B. Cold sores: how to prevent and treat them. Skin Care Guide website. Available at:
...(Click grey area to select URL)
Accessed January 29, 2021.
Oral herpes. EBSCO DynaMed website. Available at:
...(Click grey area to select URL)
Accessed January 29, 2021.
Last reviewed March 2020 by EBSCO Medical Review Board David L. Horn, MD, FACP
Last Updated: 1/29/2021

EBSCO Information Services is fully accredited by URAC. URAC is an independent, nonprofit health care accrediting organization dedicated to promoting health care quality through accreditation, certification and commendation.

This content is reviewed regularly and is updated when new and relevant evidence is made available. This information is neither intended nor implied to be a substitute for professional medical advice. Always seek the advice of your physician or other qualified health provider prior to starting any new treatment or with questions regarding a medical condition.

To send comments or feedback to our Editorial Team regarding the content please email us at healthlibrarysupport@ebsco.com. Our Health Library Support team will respond to your email request within 2 business days.

Home |Terms and Conditions |Concerned About Privacy? |Accessibility |Careers |For Employers and Medical Plan Providers

You may also be looking for: CVS/pharmacy | MinuteClinic | Specialty Pharmacy | SilverScript | Accordant