(Androblastoma; Sertoli-Leydig Cell Tumor of the Ovary)
by Amanda Barrett, MA
An arrhenoblastoma is a rare type of ovarian tumor. This tumor primarily secretes the male sex hormone, testosterone, and rarely the female sex hormone, estrogen.
Arrhenoblastomas are generally benign, meaning they do not normally spread beyond the ovary.
The cause of arrhenoblastoma is unknown.
Arrhenoblastomas are most common in young women between the ages of 20 and 30 years of age. However, they can occur at any age, including in toddlers, young girls, and postmenopausal women.
Arrhenoblastoma may also be a rare complication of pregnancy.
In many cases, infrequent menstrual periods or cessation of menstrual periods is the only symptom.
In up to 1 in 3 patients, arrhenoblastoma is accompanied by masculinization, including any of the following:
You will be asked about your symptoms and medical history. A physical exam will be done.
Your bodily fluids may be tested. This can be done with blood tests to check hormone levels.
Images may be taken of your bodily structures. This can be done with ultrasound.
Treatment involves surgery to remove one or both ovaries. This procedure is usually successful in returning normal menstruation (in premenopausal women) and ceasing masculinization. If the tumor is late stage and particularly aggressive (which is rare), radiation therapy, chemotherapy, or both, in addition to surgery, may be needed.
There are no known ways to prevent ovarian cancer of any kind, as the cause is unknown.
The Endocrine Society
Ovarian Cancer Research Fund Alliance
Canadian Cancer Society
Ovarian Cancer Canada
Choong S, Fuller P, et al. Sertoli-Leydig cell tumor of the ovary, a rare cause of precocious puberty in a 12-month-old infant. J Clin Endocrinol Metab. 2002;87:49-56.
Colombo N, Parma G, et al. Management of ovarian stromal cell tumors. J Clin Oncol. 2007;20:2944-2951.
McCluggage WG, McKenna M, et al. CD56 is a sensitive and diagnostically useful immunohistochemical marker of ovarian sex cord stromal tumor. Int J Gyn Pathol. 2007;26:322-327.
Sachdeva P, Arora R, et al. Cell tumor: a rare ovarian neoplasm. Gynecologic Endocrinology. 2008;24(4):230-234.
Sex cord-stromal tumors. Johns Hopkins Pathology website. Available at:
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Updated June 25, 2001. Accessed December 7, 2017.
Last reviewed November 2018 by Beverly Siegal, MD, FACOG
Last Updated: 12/20/2014
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